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emblem राष्ट्रीय प्रतिरक्षाविज्ञान संस्थानNational Institute of ImmunologyAn Autonomous Institute of Dept. of Biotechnology, Ministry of Science and Technology, Govt. of India

Dr. Tanmay Majumdar

Research Interest:

Integration of nutritional therapy with innate and adaptive immunity in infectious disease model

Summary of Research:

My research interest has been emergent to develop translational disease intervention strategies against important human chronic diseases by cultivating the balance between tolerance versus immunity, abrogating inflammation, mediated by gut microbiome.

Microbiome based nutritional therapy: A new arsenal against Toxoplasma gondii treatment induced obesity

The project based on the disruption of synchrony between gut microbiome and metabolic rhythms by Toxoplasma gondii infection. We ask the question, how does altered microbiome population develop obesity due to metabolic dysfunction in course of treatment of chronic T. gondii infection. Competition between symbionts vs pathobiont determines tolerance (Treg/Tr1/Breg/Br1) vs inflammation  (Th1/Th17/Inflammatory B1). Chronic infection leads to uncontrolled inflammation towards obesity. This translational research will examine mechanisms of the beneficial effects of probiotics, and will discover microbiome based new generation of anti-inflammatory small molecules against T. gondii induced obesity.

Awards:
• Ramalingaswami Fellowship, DBT, Government of India (2016)
• Santa-Cruz Biotechnology Investigator Award, USA (2016)
• International Travel Grant as Young Scientist to Portugal from DST, Government of India (2008)
• The Best Oral Presentation in 34th Indian Immunology Society Conference (2007)

Publications:
  • Shelly A., Gupta P., Ahuja R., Srichandran S., Meena J., Majumdar T.¶Impact of microbiota: a paradigm for evolving herd immunity against viral diseases. Review article, Viruses, 2020; 12:1150-1173. (based on COVID-19)
  • Majumdar T.,¶ Sharma S., Kumar M., Hussain A.M, Chauhan N., Kalia I., Sahu A.K.,   Rana V.S., Bharti R., Haldar A.K., Singh A.P., Mazumder S. Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection. Cell Death & Disease (Nature Group Publisher), 2019;10(161):1-20.
  • Srivastava N., Shelly A., Kumar M., Pant A., Das B, Majumdar T., Mazumder S. Aeromonas hydrophilautilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish. Cell Death & Discovery (Nature Group Publisher), 2017;3:17067-17076. 
  • Majumdar T., Dhar J., Patel S., Kondratov R., Barik, S. Circadian transcription factor BMAL1 provides innate immunity against select RNA viruses. Innate Immunity, 2017;23(2):147-154.
  • Wang X., Majumdar T., Kessler P., Ozhegov E., Chattopadhyay S., Barik S., Sen GC. STING requires the adaptor TRIF to trigger innate immune responses to microbial infection. Cell Host & Microbe 2016;20:329- 341.
  • Suryawanshi A., Manoharan I., Hong Y., Swafford D., Majumdar T., Manicassamy B., Thangaraju M., Koni P.A., Taketo M.M., Manicassamy S. Canonical Wnt Signaling in Dendritic Cells Regulates Th1/ Th17 Responses and Suppresses Autoimmune Neuroinflammation. J. Immunology 2015;194(7):3295-304. 
  • Majumdar T., Chattopadhyay S., Ozhegov E., Dhar J., Goswami R., Sen G.C., Barik S. Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii. PLOS Pathogens 2015;doi:10.1371/journal.ppat.1004779.g006:1-22. 
  • Hong Y., Manoharan I., Suryawanshi A., Majumdar T., Angus-Hill M.L., Koni P.A., Manicassamy B., Mellor A.L., Munn D.H., Manicassamy S. β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells. Cancer Research 2015;75:656-665. 
  • Majumdar T.,* Goswami R.,* Dhar J., Chattopadhyay S., Bandyopadhyay S.K., Verbovetskaya V., Sen G.C., Barik S. Viral degradasome hijacks mitochondria to suppress innate immunity. Cell Research 2013;23(8):1025-1042. *co-first author
  • Musiyenko A., Majumdar T., Andrews J., Adams B., Barik S. PRMT1 methylates the single Argonaute of Toxoplasma gondii and is important for the recruitment of Tudor nuclease for target RNA cleavage by antisense guide RNA. Cellular Microbiology 2012;14:882-901.
  • Haque S.J., Majumdar T., Barik S. Redox-assisted protein folding systems in eukaryotic parasites. Antioxidant Redox Signal. 2012;15:674-83. 
  • Swedan S., Andrews J., Majumdar T., Musiyenko A., Barik S. Multiple functional domains and complexes of the two nonstructural proteins of human respiratory syncytial virus contribute to interferon suppression and cellular location. J. Virology 2011;85:10090-100100. 
  • Majumdar T., Das B., Bhadra R.K., Dam B., Mazumder S. Complete nucleotide sequence of a quinolone resistance gene (qnrS2) carrying plasmid of Aeromonas hydrophilaisolated from fish. Plasmid 2011;66:79-84.
  • Jayaswal S., Kamal M.K., Dua R., Gupta S., Majumdar T., Das G., Kumar D., Rao K.V.S. Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen. PLOS Pathogens 2010;6:1-15.
  • Majumdar T., Das B., Mazumder S., Bhadra R.K. Complete sequence of the quinolone resistance gene carrying plasmid pBRST7.6 from the fish pathogen Aeromonas hydrophila. NCBI, Gene Bank Accession No. EU925817;2008. 
  • Majumdar T., Chattopadhyay P., Saha D.R., Sau S., Mazumder S. Virulence plasmid of Aeromonas hydrophilainduces macrophage apoptosis and helps in developing systemic infection in mice. Microbial Pathogenesis 2009;46:98-107.
  • Majumdar T., Datta S., Ghosh D., Dutta S., Chakraborty A., Goswami R., Mazumder S. Role of virulence plasmid of Aeromonas hydrophilain the pathogenesis of ulcerative disease syndrome in Clariasbatrachus. Indian J. Biochemistry Biophysics 2007;44:401-406. 
  • Datta S., Saha D.R., Ghosh D., Majumdar T., Bhattacharya S., Mazumder S. Sub-lethal concentration of arsenic interferes with the proliferation of hepatocytes and induces in vivo apoptosis in ClariasbatrachusL. Comparative Biochemistry Physiology 2007;145:339-349. 
  • Majumdar T., Ghosh D., Datta S., Sahoo C., Pal J., Mazumder S. An attenuated plasmid cured strain of Aeromonas hydrophilaelicits protective immunity in ClariasbatrachusL. Fish & Shellfish Immunology 2007;23:222-230. 
  • Majumdar T., Ghosh S., Pal J., Mazumder S. Possible role of a plasmid in the pathogenesis of a fish disease caused by Aeromonas hydrophila. Aquaculture 2006;256:95-104.

 

¶ corresponding author

Faculties

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