Understanding immunity and host-pathogen interactions during infection with Salmonella
Summary of Research:
Pathogenic Salmonella species produce a number of clinical manifestations in humans and animals. Salmonella typhi causes systemic infection, typhoid, in humans while non-tyhoidal Salmonella serovars such as Salmonella typhimurium produce only self-limiting localized gastroenteritis. In mice, however, infection with Salmonella typhimurium leads to a systemic disease that is analogous to human typhoid; Salmonella typhi does not establish successful infection in mice. The reasons for different clinical manifestations produced by these two very closely related Salmonella serovars and the host specificity exhibited by them are not understood. Also, the mechanism by which pathogenic Salmonella overcomes host immune defenses in order to establish systemic infection is not clear. Work in our laboratory addresses these two important issues. More specifically, our work focuses on
i) deciphering host-pathogen interactions during infection with S.typhi and S.typhimurium.
ii) understanding modulation of immune responses during infection with pathogenic Salmonella.
Debjani Dutta, Ajay Suresh Akhade, Farhat Parween, Sonia, Ram Pal
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