emblem राष्ट्रीय प्रतिरक्षाविज्ञान संस्थानNational Institute of Immunology

An Autonomous Institute of Dept. of Biotechnology, Ministry of Science and Technology, Govt. of India

सत्यजीत रथ

Research Interest:

The focus of programmes in the group has been the physiological control of the generation and activation of T, B and antigen-presenting cells (APCs), using a variety of interlinked experimental systems and approaches in association with many collaborators both within and outside NII.

Summary of Research:

Projects have examined APCs and pathways involved in antigen presentation to MHC class I and MHC class II-restricted T cells, and analysing the consequences of intracellular signal transduction modulation for development and functional responses of T cells, B cells and APCs, using genetic as well as pharmacological tools.

Group Members:
(Since 1991-)

Doctoral students: Sanjeev Kumar Mendiratta, Roshini Abraham, Pratima Bansal, Nagendra Singh, Sumeena Bhatia, Chandrashekhar Pasare, Suresh Radhakrishnan, Chitra Ebenezer, Smita Srivastava, Ashutosh Chaudhry, Abhishek Das, Divya Anna Verghese, Shalini Tanwar, Anita Mangla, Vineeta Varanasi, Thyagarajan Krishnamurthy, Hridesh Banerjee, Renu Balyan, Rupali Gund, Jasneet Kaur Khalsa, Atika Dhar, Aman Preet Singh Chawla, Bahadur Singh Gurjar, Danish Umar

Pre-doctoral fellows: Bahadur Singh Gurjar, Monique Odette Kamtchueng

Post-doctoral associates: Partha Pratima Manna, Sarita Sehra, Paushali Mukherji, Sangita Mukhopadhyay, Deepa Rajagopal, Anjani Saxena, Madhuchhanda Mohanty, Deepak Kumar Rathore, Savit Prabhu, Chaitali Banerjee
Publications:

(Original research papers since 2010-)

  • Varanasi V, Mattoo H Tupperwar NC Thyagarajan K Das A Kumar R Bal V Vaidya T George A Rath S (2010) A superantigen interacts with leishmanial infection in antigen-presenting cells to regulate cytokine commitment of responding CD4 T cells. J Infect Dis 202 1234
  • Satpathy S Shenoy GN Kaw S Vaidya T Bal V Rath S George A (2010) Inhibition of terminal differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK. J Immunol 185 6499
  • Khare A Viswanathan B Gund R Jain N Ravindran Bx George A Rath S Bal V (2011) Role of Bruton's tyrosine kinase in macrophage apoptosis. Apoptosis 16 334
  • Chatterjee P Tiwari RK Rath S Bal V George A (2012) Modulation of antigen presentation and B cell receptor signaling in B cells of beige mice. J Immunol 188 2695
  • Panda SK Kumar S Tupperwar NC Vaidya T George A Rath S Bal V Ravindran B (2012) Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks endotoxemia. PLoS Pathogens 8 e1002717
  • Shenoy GN Chatterjee P Kaw S Mukherjee S Rathore DK Bal V Rath S George A (2012) Recruitment of memory B cells to lymph nodes remote from the site of immunization requires an inflammatory stimulus. J Immunol 189 521
  • Banerjee H Das A Srivastava S Mattoo HR Thyagarajan K Khalsa JK Tanwar S Das DS Majumdar SS George A Bal V Durdik JM Rath S (2012) A role for apoptosis-inducing factor in T cell development. J Exp Med 209 1641    
  • Sinha A Gulati A Saini S Blanc C Gupta A Gurjar BS Saini H Kotresh ST Ali U Bhatia D Ohri A Kumar M Agarwal I Gulati S Anand K Vijayakumar M Sinha R Sethi S Salmona M George A Bal V Singh G Dinda AK Hari P Rath S Dragon-Durey MA Bagga A Indian HUS Registry (2014) Prompt plasma exchanges and immunosuppressive treatment improves the outcomes of anti-factor H autoantibody-associated hemolytic uremic syndrome in children. Kidney Int 85 1151
  • Saini AS Shenoy GN Rath S Bal V George A (2014) Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells. Nat Immunol 15 275
  • Upadhyay M Priya GK Ramesh P Madhavi MB Rath S Bal V George A Vaidya T (2014) CD40 signaling drives B lymphocytes into an intermediate memory-like state, poised between naïve and plasma cells. J Cell Physiol 229 1387
  • Rane S Das R Ranganathan V Prabhu S Das A Mattoo H Durdik JM George A Rath S Bal V (2014) Peripheral residence of naïve CD4 T cells induces MHC class II-dependent alterations in phenotype and function. BMC Biol 12 106
  • Rathore DK Nair D Raza S Saini S Singh R Kumar A Tripathi R Ramji S Batra A Aggarwal KC Chellani HK Arya S Bhatla N Paul VK Aggarwal R Agarwal N Mehta U Sopory S Natchu UC Bhatnagar S Bal V Rath S Wadhwa N (2015) Underweight full-term Indian neonates show differences in umbilical cord blood leukocyte phenotype: a cross-sectional study. PLoS One 10 e0123589
  • Jain N Khullar B Oswal N Banoth B Joshi P Ravindran B Panda S Basak S George A Rath S Bal V Sopory S (2016) TLR-mediated albuminuria needs TNFα-mediated cooperativity between TLRs present in hematopoietic tissues and CD80 present on non-hematopoietic tissues in mice. Dis Model Mech 9 707
  • Basu S Kaw S D'Souza L Vaidya T Bal V Rath S George A (2016) Constitutive CD40 signaling calibrates differentiation outcomes in responding B cells via multiple molecular pathways. J Immunol 197 761
  • Prabhu SB Rathore DK Nair D Chaudhary A Raza S Kanodia P Sopory S George A Rath S Bal V Tripathi R Ramji S Batra A Aggarwal KC Chellani HK Arya S Agarwal N Mehta U Natchu UC Wadhwa N Bhatnagar S (2016) Comparison of human neonatal and adult blood leukocyte subset composition phenotypes. PLoS One 11 e0162242
  • Balyan R Gund R Ebenezer C Khalsa JK Verghese DA Krishnamurthy T George A Bal V Rath S Chaudhry A (2017) Modulation of naive CD8 T cell response features by ligand density, affinity, and continued signaling via internalised TCRs. J Immunol 198 1823
  • Jain N Oswal N Chawla AS Agrawal T Biswas M Vrati S Rath S George A Bal V Medigeshi GR (2017) CD8 T cells protect adult naive mice from JEV-induced morbidity via lytic function. PLoS Negl Trop Dis 11 e0005329
  • Tanwar S Dhar A Varanasi V Mukherjee T Boppana R Basak S Bal V George A Rath S (2017) Mediation of transitional B cell maturation in the absence of functional Bruton's tyrosine kinase. Sci Rep 7 46029
  • D'Souza L Gupta SL Bal V Rath S George A (2017) CD73 expression identifies a subset of IgM+ antigen-experienced cells with memory attributes that is T cell and CD40 signalling dependent. Immunology 152 602
  • Khullar B Balyan R Oswal N Jain N Sharma A Abdin MZ Bagga A Bhatnagar S Wadhwa N Natchu UCM George A Rath S Bal V Sopory S (2017) Interaction of CD80 with Neph1: a potential mechanism of podocyte injury. Clin Exp Nephrol 22 508
  • Mukherjee T Chatterjee B Dhar A Bais SS Chawla M Roy P George A Bal V Rath S Basak S (2017) A TNF-p100 pathway subverts non-canonical NF-κB signaling in inflamed secondary lymphoid organs. EMBO J 36 3501
  • Das A Ranganathan V Umar D Thukral S George A Rath S Bal V (2017) Effector/memory CD4 T cells making either Th1 or Th2 cytokines commonly co-express T-bet and GATA-3. PLoS ONE 12(10) e0185932
  • Gurjar BS Sriharsha TM Bhasym A Prabhu S Puraswani M Khandelwal P Saini H Saini S Verma AK Chatterjee P Guchhait P Bal V George A Rath S Sahu A Sharma A Hari P Sinha A Bagga A (2018) Characterization of genetic predisposition and autoantibody profile in atypical hemolytic uremic syndrome. Immunology 154 663
  • Rathore DK Holmes TH Nadeau KC Mittal P Batra A Rosenberg-Hasson Y Sopory S Gupta R Chellani HK Aggarwal KC Bal V Natchu UCM Bhatnagar S Tavassoli M Lyell DJ Rath S Wadhwa N Maecker HT (2018) Differences in multiple immune parameters between Indian and U.S. infants. PLoS One 13(11) e0207297
  • Chawla AS Kanodia P Mukherjee A Jain V Kaur G Coshic P Chatterjee K Wadhwa N Natchu UCM Sopory S Bhatnagar S Majumder PP George A Bal V Rath S Prabhu SB (2018) intrinsic regulation of peripheral memory-phenotype T cell frequencies. PLoS One 13(12) e0200227
  • Balyan R Gund R Chawla AS Khare S Pradhan S Rane S Galande S Durdik J George A Bal V Rath S (2019) Correlation of cell-surface CD8 levels with function, phenotype and transcriptome of naive CD8 T cells. Immunology 156 384
  • Bhasym A Gurjar BS Prabhu S Puraswani M Khandelwal P Saini H Saini S Chatterjee P Bal V George A Coshic P Patidar G Hari P Sinha A Bagga A Rath S Guchhait P (2019) Altered peripheral blood leucocyte phenotype and responses in healthy individuals with homozygous deletion of FHR1 and FHR3 genes. J Clin Immunol 39 336
  • Puraswani M Khandelwal P Saini H Saini S Gurjar BS Sinha A Shende RP Maiti TK Singh AK Kanga U Ali U Agarwal I Anand K Prasad N Rajendran P Sinha R Vasudevan A Saxena A Agarwal SK Hari P Sahu A Rath S Bagga A (2019) Clinical and immunological profile of anti-factor H antibody associated atypical hemolytic uremic syndrome: A nationwide database. Front Immunol 10 1282
  • Gupta S Basu S Bal V Rath S George A (2019) Gut IgA abundance in adult life is a major determinant of resistance to DSS-colitis and can compensate for the effects of inadequate maternal IgA received by neonates. Immunology 158 19
  • Khalsa JK Chawla AS Prabhu SB Vats M Dhar A Dev G Das N Mukherjee S Durdik JM Bal V George A Rath S Arimbasseri GA (2019) Functionally significant metabolic differences between B and T lymphocyte lineages. Immunology 158 104
  • Dhar A Chawla M Chattopadhyay S Oswal N Umar D Gupta S Bal V Rath S George A Arimbasseri GA Basak S (2019) Role of NF-kappaB2-p100 in regulatory T cell homeostasis and activation. Sci Rep 9 13867
  • Kanodia P Kaur G Coshic P Chatterjee K Neeman T George A Rath S Bal V Prabhu SB (2019) Characterization of biological variation of peripheral blood immune cytome in an Indian cohort. Sci Rep 9 14735
  • Chawla AS Khalsa JK Dhar A Gupta S Umar D Arimbasseri GA Bal V George A Rath S (2020) A role for cell-autocrine interleukin-2 in regulatory T cell homeostasis. Immunology 160 295
  • Umar D Das A Gupta S Chattopadhyay S Sarkar D Mirji G Kalia J Arimbasseri GA Durdik JM Rath S George A Bal V (2020) Febrile temperature change modulates CD4 T cell differentiation via a TRPV channel-regulated Notch-dependent pathway. Proc Natl Acad Sci USA 117 22357
  • Rokade S Upadhya M Bhat DS Subhedar N Yajnik CS Ghose A Rath S Bal V (2021) Transient systemic inflammation in adult male mice results in underweight progeny. Am J Reprod Immunol 86 e13401
  • Dev G Chawla AS Gupta S Bal V George A Rath S Arimbasseri GA (2022) Differential regulation of two arms of mTORC1 pathway fine-tunes global protein synthesis in resting B lymphocytes. Int J Mol Sci 23 16017
  • Gupta S Gupta SL Singh A Oswal N Bal V Rath S George A Basu S (2023) IgA determines bacterial composition in the gut. Crohns Colitis 360 26 otad030
  • Phatak S Ingram JL Goel P Rath S Yajnik C (2023) Does hand stiffness reflect internal organ fibrosis in diabetes mellitus? Front Clin Diabetes Healthc 10 1198782