emblem राष्ट्रीय प्रतिरक्षाविज्ञान संस्थानNational Institute of Immunology

An Autonomous Institute of Dept. of Biotechnology, Ministry of Science and Technology, Govt. of India

Publications 2024

Publications 2024

  1. Aggarwal A, Nasreen A, Sharma B, Sahoo S, Aswin K, Faruq M, Pandey R, Jolly MK, Singh A, Gokhale RS, Natarajan VT. (2024) Distinct melanocyte subpopulations defined by stochastic expression of proliferation or maturation programs enable a rapid and sustainable pigmentation response. PLoS Biol. 22:e3002776.
  2. Agarwal M, Bhaskar A, Singha B, Mukhopadhyay S, Pahuja I, Singh A, Chaturvedi S, Agarwal N, Dwivedi VP, Nandicoori VK* (2024) Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis. Commun Biol. 7:949
  3. Agrawal P, Arya H, Senthil Kumar G* (2024) Structure-based identification of small- molecule inhibitors that target the DIII domain of the Dengue virus glycoprotein E pan-serotypically. PLoS One. 19:e0311548.
  4. Agarwal S, Harsukhbhai Chandpa H, Naskar S, Lal Meena C, Kumar Panda A, Meena   J (2024) Dominant B cell-T cell epitopes instigated robust immune response in-silico  against Scrub Typhus. Vaccine. 42:3899-3915
  5. Aggarwal S, Rastogi A, Maiwall R, Sevak JK, Yadav V, Maras J, Thomas SS, Kale PR, Pamecha V, Perumal N, Trehanpati N, Ramakrishna G (2024) Palmitic acid causes hepatocyte inflammation by suppressing the BMAL1-NAD<sup>+</sup>-SIRT2 axis. J Physiol Biochem. 80:845-864
  6. Ansari A, Coshic P, Sharma A, Sette A, Weiskopf D, Gupta N* (2024) T-B coculture assay for functional analysis of antigen-specific memory CD4+ T cells.  STAR Protoc. 5:103119.
  7. Archana, Gupta AK, Noumani A, Panday DK, Zaidi F, Sahu GK, Joshi G, Yadav M, Borah SJ, Susmitha V, Mohan A, Kumar A*, Solanki PR. (2024) Gut microbiota derived short-chain fatty acids in physiology and pathology: An update. Cell Biochem Funct. 42:e4108.
  8. Archana, Kumar A*, Solanki PR (2024) 4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS2 Nanosheet-Modified Molecularly Imprinted Biopolymer.  ACS Appl Bio Mater. 7:3841-3853.
  9. Arora N, Hazra JP, Roy S, Bhati GK, Gupta S, Yogendran KP, Chaudhuri A, Sagar A, Rakshit S (2024) Emergence of slip-ideal-slip behavior in tip-links serve as force  filters of sound in hearing. Nat Commun. 15:1595
  10. Bagbi Y, Sarswat A, Kumar R, Panda AK, Mohan D, Solanki PR (2024) Excellent Adsorption of Lead (II) and Chromium (VI) from Water Using Zwitterions (-NH3+ and -COO-) Functionalized Nano Lanthanum Oxide: Kinetic, Isotherm, Thermodynamic, and Surface Mechanism  Langmuir. 40: 11558-11570
  11. Baghel M, Shi SL, Patel H, Velagapudi V, Ali AM, Yadav VK (2024) Taurine/chenodeoxycholic acid ratio as a potential serum biomarker for low vitamin B<sub>12</sub> levels in humans. Br J Nutr. doi: 132:712-724
  12. Bhatnagar S, Sadhukhan D, Sundd M* (2024) Backbone assignments of the biotin carboxyl carrier protein domain of Propionyl CoA carboxylase of Leishmania major and its interaction with its cognate Biotin protein ligase. Biomol NMR Assign. 18:309-314
  13. Chakravorty S, Archana, Lakshmi G, Solanki PR, Kumar A* (2024) Trimethylamine N-oxide detection by electrochemical sensor based on screen printed electrode modified with molecularly imprinted polypyrrole-molybdenum(III) sulphide nanosheets. Colloids Surf B Biointerfaces. 244:114164.
  14. Chauhan M, Singh K, Chongtham C, A G A, Sharma P* (2024) miR-449a Mediated Repression of the Cell Cycle Machinery Prevents Neuronal Apoptosis. J Biol Chem. 300:107698.
  15. Choy MS, Nguyen HT, Kumar GS, Peti W, Kettenbach AN, Page R (2024) A protein phosphatase 1 specific <i>phos</i>phatase <i>ta</i>rgeting <i>p</i>eptide (PhosTAP) to identify the PP1 phosphatome. Proc Natl Acad Sci U S A. 121:e2415383121.
  16. Deka A, Kumar N, Basu S, Chawla M, Bhattacharya N, Ali SA, Bhawna, Madan U, Kumar S, Das B, Sengupta D, Awasthi A, Basak S* (2024) Non-canonical NF-κB signalling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies. EMBO J. 43:3895-3915
  17. Gaur V, Tyagi W, Das S, Ganguly S, Bhattacharyya J (2024) CD40 agonist engineered immunosomes modulated tumor microenvironment and showed pro-immunogenic response, reduced toxicity, and tumor free survival in mice bearing glioblastoma.  Biomaterials. 311:122688.
  18. Gulati P, Solanki P, Verma AK, Kumar A (2024) Interaction of 4-ethyl phenyl sulfate with bovine serum albumin: Experimental and molecular docking studies. PLoS One. 19:e0309057.
  19. Gupta A, Niveria K, Chandpa HH, Singh M, Kumar V, Panda AK, Meena J (2024) Stimuli- responsive magnetic silica-poly-lactic-co-glycolic acid hybrid nanoparticles for targeted cancer chemo-immunotherapy. Drug Deliv Transl Res.  14:2712-2726
  20. Gupta L, Verma S, Goswami L, Kamboj H, Sen P, Bhattacharya AK, Vijayaraghavan P (2024) Unveiling the Cell Wall-Targeting Mechanisms and Multifaceted Virulence Modulation by a Eugenol Glycoconjugate against Aspergillus fumigatus: Insights from in vitro and in ovo Studies. J Appl Microbiol. doi: 10.1093/jambio/lxae009.
  21. Gupta S, Pradhan A, Rashmi D, Mittal M, Das S, Sau AK* (2024) Helical Domain Changes between hGBP3 and hGBP3ΔC Result in Distinct Oligomers and Anti-HCV Activity. Biochemistry.63:2892-2903.
  22. Gupta S, Prem R, Sethy C, Shrivastava S, Singh M, Yadav P, Huddar VG,  Prajapati PK, Roy A, Sundd M, Patel AK (2024) Exploring Anticancer Properties of Medicinal Plants against Breast Cancer by Downregulating Human Epidermal Growth Factor Receptor 2. J Agric Food Chem. 72:9717-9734.
  23. Jalandra R, Dalal N, Mohan A, Solanki PR, Kumar A* (2024) A novel method for  enrichment of Morganella morganii in fecal samples using designed culture  medium. Cell Biochem Funct. 42:e4004.
  24. Jawla N, Kar R, Patil VS, Arimbasseri GA*(2024) Inherent metabolic preferences differentially regulate the sensitivity of Th1 and Th2 cells to ribosome- inhibiting antibiotics. Immunology.  174:73-91.
  25. Jitender, Vikram Kumar B, Singh S, Verma G, Kumar R, Mishra PM, Kumar S, Nagaraj SK, Nag J, Joy CM, Nikam B, Singh D, Pooja, Kalidas N, Singh S, Mumtaz, Bhardwaj AK, Mankotia DS, Ringe RP, Gupta N, Tripathi S, Mishra RPN. (2024) Mammalian cell expressed recombinant trimeric spike protein is a potent vaccine antigen and confers near-complete protection against SARS-CoV-2 infection in Hamster. Vaccine.42:126099.
  26. Jyotsna, Sarkar B, Yadav M, Deka A, Markandey M, Sanyal P, Nagarajan P, Gaikward N, Ahuja V, Mohanty D, Basak S, Gokhale RS* A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis. eLife. 12:RP93273.
  27. K C Y, Pal S, Nitz TJ, Wild C, Gaur R (2024) Construction of a HIV-1 subtype C 3D model using homology modeling and in-silico docking, molecular dynamics simulation, and MM-GBSA calculation of second-generation HIV-1 maturation inhibitor(s). J Biomol Struct Dyn. 42:7150-7159
  28. Kamble K, Kumar U, Aahra H, Yadav M, Bhola S, Gupta S* (2024) A novel ER stress  regulator ARL6IP5 induces reticulophagy to ameliorate the prion burden. Autophagy. doi: 10.1080/15548627.2024.2410670.
  29. Kar R, Chattopadhyay S, Sharma A, Sharma K, Sinha S, Arimbasseri GA*, Patil  S* (2024) Single-cell transcriptomic and T cell antigen receptor analysis of human  cytomegalovirus (hCMV)-specific memory T cells reveals effectors and pre-effectors of CD8+ - and CD4+ -cytotoxic T cells  Immunology.172:420-439.
  30. Kaur M, Agrawal P, Singh G, Kumar GS*, Barnwal RP (2024) Deciphering significantinteraction between Clp1 (CF IA) and Ssu72 (CPF) in pre-mRNA processing via<i>in silico</i> approaches. J Biomol Struct Dyn. doi:  10.1080/07391102.2024.2426757.
  31. Kaur M, Arya H, Sharma A, Singh G, Kumar GS,*Barnwal RP (2024)  Computational  insight into crucial interaction between Pcf11 and Ydh1 for pre-mRNA 3'-endprocessing. J Biomol Struct Dyn. doi:10.1080/07391102.2024.2438355.
  32. Kaur N, Verma AK, Girdhar M, Kumar A, Siddiqui MA, Al-Khedhairy AA, Malik T,   Mohan A (2024) Genome-wide analysis of the <i>Cannabis sativa</i> cytochrome P450monooxygenase superfamily and uncovering candidate genes for improved herbicidetolerance. Front Plant Sci. 15:1490036.
  33. Khan MT, Almas M, Malik N, Jalota A, Sharma S, Ali SA, Luthra K, Suri V, Suri A, Basak S, Seth P, Chosdol K, Sinha S (2024) STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma. Cell Signal. 119: 111178.
  34. Khan MZ, Hunt DM, Singha B, Kapoor Y, Singh NK, Prasad DVS, Dharmarajan S, Sowpati DT, de Carvalho LPS, Nandicoori VK* (2024) Divergent downstream biosynthetic pathways are supported by <sc>L</sc>-cysteine synthases of Mycobacterium tuberculosis eLife. doi: 10.7554/eLife.91970.
  35. Krishnan A, Malik G, Garg LC (2024) Immunogenicity and Neutralization Potential of Recombinant Chimeric Protein Comprising the Catalytic Region of Gp63 of Leishmania and LTB against Leishmania Donavani. Protein Pept Lett.. 31:696-705
  36. Kumar A, Saha MK, Kumar V, Bhattacharya A, Barge S, Mukherjee AK,   Kalita    MC, Khan MR. Correction: Heat‑killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans. Immun Ageing.  doi: 10.1186/s12979-024-00464-x. Erratum for: Immun Ageing. 21:52
  37. Kumar GS* (2024) Preparation of Oxidized and Reduced PTP4A1 for Structural and  Functional Studies. Methods Mol Biol. 2743:211-222
  38. Kumar MM, Arindkar S, Saini M, Nagarajan P (2024) Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation: Evaluating susceptibility to the development of obesity and NAFLD.  Genes &  Diseases. 11:100982
  39. Kumar R, Kumari P, Gaurav N, Kumar R, Singh D, Malhotra P, Singh SK, Bhatta RS, Kumar A, Nagarajan P, Singh S, Dalal N, Roy BG, Bhatt AN, Chandna S  (2024) N-acetyl-L-tryptophan provides radioprotection to mouse and primate models byantagonizing the TRPV1 receptor and substance P inhibition. Int J Radiat Biol..doi: 10.1080/09553002.2024.2435330.
  40. Kumar S, Mohan A, Sharma NR, Kumar A, Girdhar M, Malik T, Verma AK. (2024) Computational Frontiers in Aptamer-Based Nanomedicine for Precision Therapeutics: A Comprehensive  review. ACS Omega. 9:26838-26862.
  41. Kumari N, Kaur E, Raghavan SC, Sengupta S* (2024) Regulation of pathway choice inDNA repair after double-strand breaks. Curr Opin Pharmacol. 80:102496.
  42. Kushwaha S, Shome P, Sehgal D* Antigen-driven Convergent Evolution of   Polysaccharide-specific "DH-less" B Cells in Glycoconjugate Immunized Mice. Immunohorizons. 8:511-526.
  43. Mandal S, Nag S, Mukherjee O, Das N, Banerjee P, Majumdar T, Mukhopadhyay S,Maedler K, Kundu R (2024) CD36 inhibition corrects lipid-FetuinA mediated insulinsecretory defects by preventing intracellular lipid accumulation andinflammation in the pancreatic beta cells. Biochim Biophys Acta Mol Basis Dis.1871:167580.
  44. Mehra P, Kumar A* (2024) Emerging importance of stool preservation methods in OMICS  studies with special focus on cancer biology. Cell Biochem Funct. 42:e4063.
  45. Mukherjee T, Kumar N, Chawla M, Philpott DJ, Basak S* (2024) The NF-κB signalling  system in the immunopathogenesis of inflammatory bowel disease. Sci Signal. 17:eadh1641.
  46. Nag S, Mandal S, Mukherjee O, Majumdar T, Mukhopadhyay S, Kundu R  (2024) Vildagliptin inhibits high fat and fetuin-A mediated DPP-4 expression,  intracellular lipid accumulation and improves insulin secretory defects in  pancreatic beta cells. Biochim Biophys Acta Mol Basis Dis. 1870:167047
  47. Pandey R, Kaul G, Akhir A, Saxena D, Shukla M, Mundra S, Zohib M, Singh S, Pal RK, Tripathi S, Jain A, Chopra S, Arora A. (2024) Characterization of structure of peptidyl-tRNA hydrolase from Enterococcus faecium and its inhibition by a pyrrolinone compound. Int J Biol Macromol. 275:133445.
  48. Rashid A, Azad M*, Krishnan A, Gupta JC, Talwar GP. (2024) Expression, purification and characterization of a novel triple fusion protein developed for the immunotherapy of survivin positive cancers. Protein Expr Purif. 226:106614.
  49. Rashmi D, Gupta S, Kausar T, Sau AK* (2024) Helical domain of hGBP3 cannot stimulate the second phosphate cleavage of GTP. J Biol Chem. 300:105696
  50. Rautela U, Sarkar GC, Chaudhary A, Chatterjee D, Rosh M, Arimbasseri AG, Mukhopadhyay A* (2024) A non-canonical role of somatic Cyclin D/CYD-1 in oogenesis andin maintenance of  reproductive fidelity, dependent on the FOXO/DAF-16 activationstate. PLoS Genet. 20:e1011453.
  51. Roshanara, Tandon R, Baig MS, Das S, Srivastava R, Puri N, Nakhasi HL, Selvapandiyan (2024) Identifying Rab2 Protein as a Key Interactor of Centrin1 Essential for Leishmania donovani Growth ACS Infect Dis. 10: 3273-3288
  52. Sahu D, Gupta C, Yennamalli RM, Sharma S, Roy S, Hasan S, Gupta P, Sharma VK, Kashyap S, Kumar S, Dwivedi VP, Zhao X, Panda AK, Das HR, Liu CJ. Author Correction: Novel peptide inhibitor of human tumor necrosis factor-α has antiarthritic activity. Sci Rep. 14:14306.
  53. Sapra L, Saini C, Sharma S, Nanda D, Nilakhe A, Chattopadhyay N, Meena AS, Mishra PK, Gupta S, Garg B, Manhas V, Srivastava RK (2024) Targeting the osteoclastogenic cytokine IL-9 as a novel immunotherapeutic strategy in mitigating inflammatory bone loss in post-menopausal osteoporosis. JBMR Plus. 8:ziae120.
  54. Saurav S, Sharma P, Kumar A*, Tabassum Z, Girdhar M, Mamidi N, Mohan A (2024) Harnessing Natural Polymers for Nano-Scaffolds in Bone Tissue Engineering: A Comprehensive Overview of Bone Disease Treatment. Curr Issues Mol Biol. 46:585-611.
  55. Sharma P, Saurav S, Tabassum Z, Sood B, Kumar A, Malik T, Mohan A, Girdhar M (2024) Applications and interventions of polymers and nanomaterials in alveolar boneregeneration and tooth dentistry. RSC Adv. 14:36226-36245.
  56. Shukla S, Murmu S, Mora T, Dhanasekaran K, Roy RP (2024) Unravelling HDAC Selectivity for Erasing Acetyl Mark on Lys-5 of Histone H2B. Chembiochem.  22:e202300875.
  57. Singh D, Tripathi P, Sharma R, Grover S, Batra JK (2024)  Singh D, Tripathi P, Sharma R, Grover S, Batra JK. Role of a substrate binding pocket in the amino terminal domain of Mycobacterium tuberculosis caseinolytic protease B (ClpB) in its function. J Biomol Struct Dyn. 42:6189-6199.
  58. Singha B, Murmu S, Nair T, Rawat RS, Sharma AK, Soni V  (2024) Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance. Metabolites14:63.
  59. Sinha P, Bhardwaj V, Muniyasamy A, Mohan KV, Jain K, Chaudhary K, Upadhyay P* (2024) Monocyte Transcriptome in Different Phases of Chronic Hepatitis B Virus Infection Uncovers Potential Functional Roles. Viral Immunol.37:287-297.
  60. Sood C, Verma JK, Basak R, Kapoor A, Gupta S, Mukhopadhyay A (2024) Leishmania  highjack host lipid body for its proliferation in macrophages by overexpressing  host Rab18 and TRAPPC9 by downregulating miR-1914-3p expression. PLoS Pathog. 20:e1012024.
  61. Tyagi W, Das S* (2024) Temporal regulation of acetylation status determines PARP1 role in DNA damage response and metabolic homeostasis. Sci Adv. 10:eado7720.
  62. Upadhyay C, Bhattacharya S, Kumar S, Vashisht K, Zhang X, Gagnon D, Singh P,Zhan P, Richard D, Rathi B, Prasad Singh A*, Singh P (2024) Synthesis and Evaluation ofFluorinated Piperazine-Hydroxyethylamine Analogues as Potential AntiplasmodialCandidates. ChemMedChem. 8:e202400616.
  63. Verma S, Dangi RS, Rajak MK, Pal RK, Sundd M* (2024) The apo-acyl coenzyme A binding  protein of Leishmania major forms a unique 'AXXA' motif mediated dimer. Biochim  Biophys Acta Proteins Proteom. 1872:141016.
  64. Worthmann A, Ridder J, Piel SYL, Evangelakos I, Musfeldt M, Voß H, O'Farrell M, Fischer AW, Adak S, Sundd M, Siffeti H, Haumann F, Kloth K, Bierhals T, Heine M, Pertzborn P, Pauly M, Scholz JJ, Kundu S, Fuh MM, Neu A, Tödter K, Hempel M, Knippschild U, Semenkovich CF, Schlüter H, Heeren J, Scheja L, Kubisch C, Schlein C (2024) Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use. Nat Commun.15:45.
  65. Yadav M, Vaishkiar I, Sharma A, Shukla A, Mohan A, Girdhar M, Kumar A, Malik T, Mohan A (2024) Oestrogen receptor positive breast cancer and its embedded mechanism: breast cancer resistance to conventional drugs and related therapies, a review. Open Biol. 14:230272.
  66. Yadav P, Jain R, Yadav RK* (2024) Emerging roles of cancer-associated histone mutations in genomic instabilities. Front Cell Dev Biol. 12:1455572.
  67. Yadav P, Rana K, Nardini V, Khan A, Pani T, Kar A, Jain D, Chakraborty R,  Singh R, Jha SK, Mehta D, Sharma H, Sharma RD, Deo SVS, Sengupta S, Patil VS, Faccioli LH, Dasgupta U, Bajaj A (2024) Engineered nanomicelles inhibit the tumour  progression via abrogating the prostaglandin-mediated immunosuppression. J  Control Release. 368:548-565.
  68. Yadav V, Zohib M, Singh S, Pal RK, Tripathi S, Jain A, Biswal BK, Dasgupta A,  Arora A (2024) Structural and biophysical characterization of PadR family protein Rv1176c of Mycobacterium tuberculosis H37Rv. Int J Biol Macromol. 263:130455.